Dicyclohexylcarbodiimide → {{5,5-Dimethyl-8-(1,2-dimethylheptyl)-10-[4-(2-methylpiperidino)-2-methylbutyryloxy]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridin-2-yl}-acetyl}urea hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Dicyclohexylcarbodiimide	HCID 10868	—
Reactant	{[10-Hydroxy-5,5-dimethyl-8-(1,2-dimethylheptyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridin-2-yl]acetyl}urea	HCID 20388001	—
Reactant	[4-(2-Methylpiperidino)]-2-methylbutyric acid hydrochloride	HCID 70607287	—
Product	{{5,5-Dimethyl-8-(1,2-dimethylheptyl)-10-[4-(2-methylpiperidino)-2-methylbutyryloxy]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridin-2-yl}-acetyl}urea hydrochloride	HCID 70607839	—

Reaction Steps

The above-titled compound was prepared according to the method of Example 8 by reacting equimolar quantities of {[10-hydroxy-5,5-dimethyl-8-(1,2-dimethylheptyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridin-2-yl]acetyl}urea and [4-(2-methylpiperidino)]-2-methylbutyric acid hydrochloride in the presence of dicyclohexylcarbodiimide.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04172943
Source dataset	uspto-grants-1979_10
ORD ID	ord-f8d208c143214b938a65d2c211b9bdab
Source note	uspto-grants-1979_10