Water → HCID 20388095, compound

Participants

Reaction Steps

The product of step (a) is dissolved in tetrahydrofuran (10 ml) and 0.1 N aqueous sodium hydroxide (12 ml) is added. After 30 minutes the solution is added to water and washed with ether. The aqueous layer is acidified with 2 N hydrochloric acid and extracted with ethyl acetate. The extract is dried, evaporated and the residue chromatographed on silica gel (10 g) eluting with hexane:ethyl acetate:acetic acid 60:40:2, to afford dl-2-(4-methoxy-5-oxo-5H-dibenzo[a,d]cyclohepten-2-yl)-propionic acid, mp 144°-147° (ethyl acetate-hexane).

Provenance & Evidence