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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 427221Generated: October 30, 2026

Phosphorus tribromide → N9-cyclohexylethyl-8-bromomethyladenine

https://huagongshe.com/reaction/427221

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus tribromideHCID 24614—
ReactantN9-cyclohexylethyl-8-hydroxymethyladenineHCID 53681681—
SolventDichloromethaneHCID 6344—
ProductN9-cyclohexylethyl-8-bromomethyladenineHCID 54368200—

Reaction Steps

A solution of N9-cyclohexylethyl-8-hydroxymethyladenine (1 mmol) in methylene chloride was treated with PBr3 (1 mmol) at 25° C. for 1 h. Extraction and chromatography give N9-cyclohexylethyl-8-bromomethyl-adenine as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06312662B1
Source datasetuspto-grants-2001_11
ORD IDord-4423c870eded450da259555888ef89d3
Source noteuspto-grants-2001_11