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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 427222Generated: October 30, 2026

Dimethylformamide → N9-cyclohexylethyl-8-diethylphosphonomethoxy-methyladenine

https://huagongshe.com/reaction/427222

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantN9-cyclohexylethyl-8-bromomethyladenineHCID 54368200—
ReactantDiethyl hydroxymethylphosphonate sodium saltHCID 86585098—
ProductN9-cyclohexylethyl-8-diethylphosphonomethoxy-methyladenineHCID 86585097—

Reaction Steps

A solution of N9-cyclohexylethyl-8-bromomethyladenine (1 mmol) in DMF was treated with a solution of diethyl hydroxymethylphosphonate sodium salt (1 mmol) in DMF at 25° C. for 1 h. Extraction and chromatography gave N9-cyclohexylethyl-8-diethylphosphonomethoxy-methyladenine as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06312662B1
Source datasetuspto-grants-2001_11
ORD IDord-d950c0a9ed1545368c09a2825772a80e
Source noteuspto-grants-2001_11