反应详情

20.0 g of 5-bromo-2-chlorobenzyl alcohol was dissolved in 100 ml of ethylene glycol dimethyl ether. To this solution, 9.4 g of phosphorus tribromide was added at −20° C., followed by stirring at room temperature for 1 hour. To the reaction solution, water was added, followed by extraction with toluene, and washing with an aqueous sodium hydrogencarbonate solution. The organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 24.9 g of a crude product of 5-bromo-2-chlorobenzyl bromide as white crystals.

1. extractionfollowed by extraction with toluene
2. washwashing with an aqueous sodium hydrogencarbonate solution
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. distillationThe solvent was distilled off under reduced pressure