Dimethylformamide → HCID 18356903, compound

Participants

Reaction Steps

7.9 g of product of Stage A, 50 ml of DMF and 11.93 g of potassium carbonate are agitated for 15 minutes at 110° C., dried in an oven under phosphoric anhydride. A solution of 15.83 g of N-(4-bromobutyl)phthalimide in 30 ml of DMF is added dropwise at ambient temperature. Agitation is carried out for one hour at 110° C. The reaction medium is poured into sodium acid phosphate, followed by evaporation under reduced pressure. 19.11 g of crude product is obtained which is purified on silica eluting with a methylene chloride-methanol-ammonium hydroxide mixture 97-3-05. 4.58 g of sought product is obtained.

Provenance & Evidence