Triethylamine → HCID 69960675, compound

Participants

Reaction Steps

Whilst cooling externally with ice 1.377 g (7.998 mmol) of pyrocatechol sulfate was added to a solution of 2.000 g (3.974 mmol) of 1-(4-amino-3,5-dibromo-D-phenylalanyl)-4-(1-methyl-4-piperidinyl)piperazine and 0.61 mL (0.004 mmol) of triethylamine in 50 mL of dimethylformamide and the mixture was then stirred for 1 hour whilst still being cooled with ice and for 2 hours at room temperature. The reaction mixture was concentrated by evaporation in vacuo at a maximum bath temperature of +40° C., the residue was triturated with diethylether, dried in air and used in the next step without further purification. Yield: 2.68 g (100% of theory).

Provenance & Evidence