Trifluoroacetic acid → HCID 9862729, compound

Participants

Reaction Steps

The title compound was prepared in a 19% yield by reacting {[3-(5-fluoro-1H-indol-3-yl)-propylamino]-methyl}-3,4-dihydro-benzo [1,4]oxazine-4-carboxylic acid tert-butyl ester (0.49 g, 1.1 mmol) with trifluoroacetic acid (20 mL) in methylene chloride (20 mL). The reaction mixture was stirred at room temperature for two hours and then poured into saturated sodium carbonate and extracted with methylene chlloride. The organic layer was dried over anhydrous sodium sulfate, filtered and chromatographed (5% MeOH in methylene chloride) afforded 0.06 g (19%) of product as an oil. The oxalate salt was prepared in ethanol: mp 168-170° C.

Provenance & Evidence