HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 4-(piperidin-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 4-(piperidin-1-yl)benzoate | HCID 13813852 | — |
Reaction Steps
Reaction of ethyl 4-fluorobenzoate with piperidine (3 equivalents) in acetonitrile was carried out at reflux for 4 days. Dilution of the cooled reaction mixture with several volumes of water provided a precipitate, which was filtered to provide ethyl 4-(piperidin-1-yl)benzoate. Reduction of the ester with lithium aluminum hydride (2 equivalents) in tetrahydrofuran gave the corresponding alcohol (Examples 71, 72).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313100B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-c8b15264a4eb4c2e9a59dd9bdeae15d9 |
| Source note | uspto-grants-2001_11 |