HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 2-(Piperidin-1-yl)-4-methoxybenzothiazole-7-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phosphine, (1-methylethylidene)bis[diphenyl- | HCID 12091099 | — |
| Reactant | 7-Bromo-2-(piperidin-1-yl)-4-methoxybenzothiazole | HCID 18357009 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(Piperidin-1-yl)-4-methoxybenzothiazole-7-carboxylic acid | HCID 18356998 | — |
Reaction Steps
Starting from 7-bromo-2-(piperidin-1-yl)-4-methoxybenzothiazole (1.4 g), palladium (II) acetate (100 mg), bis-diphenylphosphinopropane (350 mg), and triethylamine (6 ml) in tetrahydrofuran (200 ml) and water (20 ml). Trituration ofthe residue with diethyl ether yielded the title compound as a yellow solid (700 mg). TLC Rf 0.66 (ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313116B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-673132dfd144492887af786fe497a62c |
| Source note | uspto-grants-2001_11 |