HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenol → 2-(Piperidin-1-yl)-4-methoxybenzothiazole-7-carboxylic acid 4-nitrophenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2-(Piperidin-1-yl)-4-methoxybenzothiazole-7-carboxylic acid | HCID 18356998 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Piperidin-1-yl)-4-methoxybenzothiazole-7-carboxylic acid 4-nitrophenyl ester | HCID 69691118 | 89.3% |
Reaction Steps
Starting from 2-(piperidin-1-yl)-4-methoxybenzothiazole-7-carboxylic acid (190 mg), p-nitrophenol (100 mg), and 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (150 mg) in dichloromethane (20 ml). Purification by column chromatography (eluent 50% ethylacetate in hexane) yielded the title compound as an off-white solid (240 mg). TLC Rf 0.39 (50% ethyl acetate in hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313116B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-194e90f9cb9d4cffb94228149b59a5c9 |
| Source note | uspto-grants-2001_11 |