5-Amino-1-methyl-1H-pyrazole-4-carbonitrile → HCID 10117651, compound

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Reaction Steps

Starting from 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (119 mg) in dimethyl fonnamide (10 ml), sodium hexamethyldisilazide in tetrahydrofuran (0.97 ml, 1.0 M), 2-(4-tert-butoxycarbonylpiperazin-1-yl)-4-methoxybenzothiazole-7-carboxylic acid 4-nitrophenyl ester (250 mg). Purification by flash chromatography (eluent 5% methanol in dichloromethane) followed by trituration with diethyl ether yielded the title compound as a pale yellow solid (260 mg). TLC Rf 0.48 (ethyl acetate); Mpt 231-232° C.

Provenance & Evidence