Diethyl Ether → (R)-N-[5-Methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide Hydrogen 1,2-Ethanedisulfonate

Participants

Reaction Steps

(R)-N-[5-Methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide (100 mg, 0.22 mmol) was dissolved in tetrahydrofuran (3 mL) by heating and 1,2-ethanedisulfonic acid dihydrate (55 mg, 0.24 mmol), dissolved in tetrahydfofuran (2 mL), was added dropwise. Diethyl ether (2 mL) was added, the solid was filtered and washed with tetrahydrofuran/diethyl ether to give a white solid that was stored in an exicator over blue gel: mp 220° C. (decom.). Anal. Calcd. for C27H36N4O2×C2H6O6S2×4H2O: C, 48.9; H, 7.1; N, 7.9. Found: C, 49.1; H, 6.8;N, 7.6.

Provenance & Evidence