HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → tert-butyl (2S)-2-(tert-butylcarbamoyl)pyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-butyl (2S)-2-(tert-butylcarbamoyl)pyrrolidine-1-carboxylate | HCID 677832 | — |
Reaction Steps
In a DMF solution of 0.50 g of Boc-Pro-OH, 0.24 ml of tert-butylamine, 0.36 g of HOBt and 0.53 g of EDC hydrochloride were added under ice cooling and the mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 28 (Process 2) to give 373 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313094B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-4df5aec7976f4c659da6e6d30d9c82ad |
| Source note | uspto-grants-2001_11 |