HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 131722957, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 131722957 | HCID 131722957 | — |
Reaction Steps
Deprotection of 100 mg of the compound obtained by the process 1 was performed similarly to that in Example 28 (Process 3), and the obtained product was dissolved in 3 ml of DMF and neutralized with 68 μl of triethylamine under ice cooling. To the neutralized solution, 107 mg of Boc-Pro-OH, 237 mg of Bop reagent and 137 μl of triethylamine were added and the resultant mixture was stirred for 2 hr. The reaction mixture was treated similarly to that in Example 86 (Process 3) to give 35 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313094B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-2eb6e91d5eb74d23a1ec33da3a955ede |
| Source note | uspto-grants-2001_11 |