HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-methyl-1-propanol → Boc-Thz-NH-C(CH3)2-CH2OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-methyl-1-propanol | HCID 11807 | — |
| Reactant | (4R)-3-[(tert-butoxy)carbonyl]-1,3-thiazolidine-4-carboxylic acid | HCID 688405 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Boc-Thz-NH-C(CH3)2-CH2OH | HCID 131722959 | — |
Reaction Steps
In a methylene chloride solution containing 0.30 g of Boc-Thz-OH, 0.12 ml of 2-amino-2-methyl-1-propanol and 0.29 g of EDC hydrochloride were added and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 33 (Process 3) to give 190 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313094B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-06293d83d3264208ab16155891ce2d51 |
| Source note | uspto-grants-2001_11 |