反应详情

To a solution of cis-1,2-cyclohexane dicarboxylic anhydride (1.0 g, 6.49 mmol) in CH2Cl2 (16 mL) was added morpholine (0.56 g, 6.49 mmol) at 0° C., the resulting mixture was allowed to stir at room temperature overnight (20 h). When complete the reaction mixture was washed with HCl (1.0 N, 20 mL) then with H2O (2×20 mL). The combined aqueous layers were extracted with CH2Cl2 (3×10 mL), and the combined organic layers were dried over MgSO4, the solvent was evaporated in vacuo to give the title compound (1.4 g, 90%/) as a white solid which was used later without further purification.

1. washWhen complete the reaction mixture was washed with HCl (1.0 N, 20 mL)
2. extractionThe combined aqueous layers were extracted with CH2Cl2 (3×10 mL)
3. dry with materialthe combined organic layers were dried over MgSO4
4. customthe solvent was evaporated in vacuo