(R)-2-(Cyclohexylmethyl)succinic acid-1-methyl ester → HCID 178520545, compound

HRID 427394Notes

Reaction equation

HRID 427394 reaction equation
N1(C(C2CCCCC2C(O)=O)=O)CCOCC1.[Cl:18][C:19]1[CH:34]=[CH:33][C:22]2[NH:23][C:24]([C:26]3[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=3)=[N:25][C:21]=2[CH:20]=1.C[O:36][C:37](=[O:50])[C@H:38]([CH2:43][CH:44]1[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]1)[CH2:39][C:40](O)=[O:41]>>[Cl:18][C:19]1[CH:34]=[CH:33][C:22]2[NH:23][C:24]([C:26]3[CH:27]=[CH:28][C:29]([NH:32][C:40](=[O:41])[CH2:39][CH:38]([CH2:43][CH:44]4[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]4)[C:37]([OH:50])=[O:36])=[CH:30][CH:31]=3)=[N:25][C:21]=2[CH:20]=1

Participants

4

Reactant 3

HCID 2734511(R)-2-(Cyclohexylmethyl)succinic acid-1-methyl esterHCID 31145632-(Morpholine-4-carbonyl)cyclohexane-1-carboxylic acidHCID 178507426HCID 178507426, compound

Product 1

HCID 178520545HCID 178520545, compoundYield 51%

Procedure

This compound was prepared by the procedure described in Example 1 part (a) from 4-(5-Chloro-1H-benzoimidazol-2-yl) phenylamine and (R)-2-(Cyclohexylmethyl) succinic acid 1-methyl ester to give the crude product (2.0 g, 51%), which was used in the next step without further purification.

Workup

  1. customThis compound was prepared by the procedure

Sources & evidence

ORD record
ord-753ef3041f82408cb8be14e82ecc9497
Source dataset
uspto-grants-2001_11
Patent number
US06313117B1

Reaction notes

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