Water → HCID 18357045, compound

Participants

Reaction Steps

A solution of 1-(4-hydroxyphenyl)-4-(4-pyridyl)piperazine (670 mg), 4-fluorobenzonitrile (354 mg) and powdered potassium carbonate (445 mg) was stirred at 95° C. in DMSO (12 ml) for 18 hours. The solution was poured into water (180 ml) to give a precipitate which was filtered, washed with water and dried. The solid was purified by chromatography on alumina (ICN Alumina N 32-63) using 1% methanol in dichloromethane as eluant. This gave a solid which was recrystallised from a mixture of ethyl acetate/isohexane to give 1-(4-cyanophenoxyphenyl)-4-(4-pyridyl)piperazine (126 mg) as a solid. m.p. 180-182° C.

Provenance & Evidence