Water → HCID 70235886, compound

Participants

Reaction Steps

Sodium hydride (120 mg) (50% dispersion in oil) was added to a stirred solution of 1-(4-hydroxyphenyl)-4-(4-pyridyl)piperazine (510 mg) in dimethylformamide (5 ml) under argon. The solution was stirred at ambient temperature for 30 minutes and a solution of 4-cyanobenzylbromide (430 mg) in dimethyl formamide (5 ml) was added dropwise. The solution was stirred at ambient temperature overnight, water (150 ml) added to give a precipitate which was washed with water, dried and recrystallised from ethanol to give 1-(4-cyanobenzyloxyphenyl)-4-(4-pyridyl)piperazine (660 mg), m.p.212-214° C.

Provenance & Evidence