4-Methylbenzaldehyde → 1-[4-(4-Methylphenylpropionyl)-phenyl]-4-(4-pyridyl)piperazine

Participants

Role	Name	HCID	Charge
Reactant	4-Methylbenzaldehyde	HCID 7725	—
Reactant	1-(4-Acetylphenyl)-4-(4-pyridyl)piperazine	HCID 18357135	—
Product	1-[4-(4-Methylphenylpropionyl)-phenyl]-4-(4-pyridyl)piperazine	HCID 54375062	27%

Reaction Steps

Using an analogous procedure to that described in Example 39, but using as starting material 1-(4-acetylphenyl)-4-(4-pyridyl)piperazine in place of 1-(4-formylphenyl)-4-(4pyridyl)piperazine and 4-tolualdehyde in place of 4-methylacetophenone, was prepared 1-[4-(4-methylphenylpropionyl)-phenyl]-4-(4-pyridyl)piperazine (27% yield), m.p. 130-132° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06313127B1
Source dataset	uspto-grants-2001_11
ORD ID	ord-4a2631dd914e4c0686d693973e477eeb
Source note	uspto-grants-2001_11