Sodium Hydroxide → HCID 18357091, compound

Participants

Reaction Steps

1-(4-Methoxycarbonylphenylmethyl)-4-(4-pyridyl)piperazine (4.5 g) was dissolved in methanol (50 ml) and treated at ambient temperature with 2M aqueous sodium hydroxide (36 ml). The resulting solution was stirred at room temperature for 3 hours and concentrated by evaporation to an aqueous solution of the sodium salt of the acid. This solution was just acidified with glacial acetic acid (4.3 ml) to give a white precipitate which was collected by filtration, washed with water and dried to give 1-(4-carboxyphenylmethyl)-4-(4-pyridyl)piperazine in 90% yield.

Provenance & Evidence