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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 427477Erstellt: 25. Oktober 2026

Succinic anhydride → 4-(2-(((8-(2-Ethyl-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)carbonyl)amino)ethoxy)-4-oxobutanoic acid

https://huagongshe.com/reaction/427477

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktSuccinic anhydrideHCID 7922—
Edukt2,3 dimethyl-8-(2-ethyl-6-methylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamideHCID 9821241—
LösungsmittelAcetoneHCID 180—
Produkt4-(2-(((8-(2-Ethyl-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)carbonyl)amino)ethoxy)-4-oxobutanoic acidHCID 9956828227,9%

Reaktionsschritte

2,3 dimethyl-8-(2-ethyl-6-methylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide (250 mg, 0.263 mmol) and succinic anhydride (100 mg, 1.00 mmol) were added to 7 ml of acetone. The mixture was refluxed for 48 h. The presiptated product was filtered off and washed with acetone and ether to give 288 mg (91%) of the title compound.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS06313136B1
Quelldatensatzuspto-grants-2001_11
ORD IDord-c49061fc08704fe09f59989ea9789a07
Quellennotizuspto-grants-2001_11