HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Succinic anhydride → 4-(2-(((8-(2-Ethyl-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)carbonyl)amino)ethoxy)-4-oxobutanoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Succinic anhydride | HCID 7922 | — |
| Edukt | 2,3 dimethyl-8-(2-ethyl-6-methylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide | HCID 9821241 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Produkt | 4-(2-(((8-(2-Ethyl-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)carbonyl)amino)ethoxy)-4-oxobutanoic acid | HCID 9956828 | 227,9% |
Reaktionsschritte
2,3 dimethyl-8-(2-ethyl-6-methylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide (250 mg, 0.263 mmol) and succinic anhydride (100 mg, 1.00 mmol) were added to 7 ml of acetone. The mixture was refluxed for 48 h. The presiptated product was filtered off and washed with acetone and ether to give 288 mg (91%) of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06313136B1 |
| Quelldatensatz | uspto-grants-2001_11 |
| ORD ID | ord-c49061fc08704fe09f59989ea9789a07 |
| Quellennotiz | uspto-grants-2001_11 |