Sodium Hydroxide → HCID 18357429, compound

HRID 427478Notes

Reaction equation

HRID 427478 reaction equation
[CH2:1]([C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[CH2:5][NH:6][C:7]1[C:8]2[N:9]([C:16]([CH3:20])=[C:17]([CH3:19])[N:18]=2)[CH:10]=[C:11]([C:13](N)=[O:14])[CH:12]=1)[CH3:2].[OH-:25].[Na+]>C(O)C>[CH2:1]([C:3]1[CH:24]=[CH:23][CH:22]=[CH:21][C:4]=1[CH2:5][NH:6][C:7]1[C:8]2[N:9]([C:16]([CH3:20])=[C:17]([CH3:19])[N:18]=2)[CH:10]=[C:11]([C:13]([OH:14])=[O:25])[CH:12]=1)[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9818607HCID 9818607, compound

Product 1

HCID 18357429HCID 18357429, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8-(2-ethylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide (1.0 g, 0.0031 mol) and sodium hydroxide (1.2 g, 0.031 mol) were solved in ethanol (95%)(30 ml) and was refluxed overnight. The solvent was evaporated under reduced pressure and to the residue was added water. The pH was adjusted to 7 by addition of conc HCl (2.6 ml) and the solid that precipitated was isolated by filtration, washed with water and dried to give 1.0 g (99%) of the title compound.

Workup

  1. temperaturewas refluxed overnight
  2. customThe solvent was evaporated under reduced pressure and to the residue
  3. additionwas added water
  4. additionThe pH was adjusted to 7 by addition of conc HCl (2.6 ml)
  5. customthe solid that precipitated
  6. customwas isolated by filtration
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-9653ca77047349f19c975287556a51fa
Source dataset
uspto-grants-2001_11
Patent number
US06313136B1

Reaction notes

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