反应详情

8-(2-ethyl-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide mesylate (11.0 g, 0.025 mol) and sodium hydroxide (7.0 g, 0.17 mol) were solved in ethanol(95%) (120 ml) and was refluxed for 20 h. The solvent was evaporated under reduced pressure and to the residue was added water (150 ml). The pH was adjusted to 5 by addition of conc HCl and acetic acid and the solid that precipitated was isolated by filtration, washed with water and acetone, and dried to give 7.6 g (88%) of the title compound.

1. temperaturewas refluxed for 20 h
2. customThe solvent was evaporated under reduced pressure and to the residue
3. additionwas added water (150 ml)
4. additionThe pH was adjusted to 5 by addition of conc HCl and acetic acid
5. customthe solid that precipitated
6. customwas isolated by filtration
7. washwashed with water and acetone
8. customdried