反应详情

8-(2-ethyl-6-methylbenzylamino)-3-hydroxymethyl-2-methylimidazo[1,2-a]pyridine-6-carboxamide (0.02 g, 0.057 m mol) and sodium hydroxide (0.02 g, 0.29 mmol) were solved in ethanol (95%) (1 ml) and was refluxed for 20 h. The solvent was evaporated under reduced pressure and to the residue was added water (1 ml). The pH was adjusted to 5 by addition of acetic acid and the solid that precipitated was isolated by filtration, washed with water and dried to give 0.012 g (60%) of the title compound.

1. temperaturewas refluxed for 20 h
2. customThe solvent was evaporated under reduced pressure and to the residue
3. additionwas added water (1 ml)
4. additionThe pH was adjusted to 5 by addition of acetic acid
5. customthe solid that precipitated
6. customwas isolated by filtration
7. washwashed with water
8. customdried