反应详情

8-Amino-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide (0.6 g, 2.9 mmol), 2,6-dimethylbenzylchloride (0.45 g, 2.9 mmol), sodium carbonate (1.0 g, 9.4 mmol) and potassium iodide (0.2 g, 1.3 mmol) were added to acetone (25 ml) and refluxed for 19 h. Methylene chloride was added and inorganic salts were filtered off. The solution was washed with a bicarbonate solution, the organic layer was separated, dried and the solvents were evaporated under reduced pressure. The residue was purified by column chromatography on silica gel using methylene chloride:methanol (100:5) as eluent and the product was washed with diethyl ether to give 0.78 g (82%) of the title compound.

1. temperaturerefluxed for 19 h
2. filtrationinorganic salts were filtered off
3. washThe solution was washed with a bicarbonate solution
4. customthe organic layer was separated
5. customdried
6. customthe solvents were evaporated under reduced pressure
7. customThe residue was purified by column chromatography on silica gel
8. washthe product was washed with diethyl ether