反应详情

2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxylic acid (0.3 g, 0.88 mmol) and o-Benzotriazol-1-yl-N,N,N′,N′-Tetramethyluronium tetrafluoroborate (TBTU)(0.29 g, 0.90 mmol) were added to methylene chloride (15 ml) and the mixture was stirred for 5 min. Ethanolamin (0.11 g, 1.8 mmol) was added and the reaction mixture was stirred at ambient temperature for 2 h. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel using methylene chloride:methanol (9:1) as eluent. Crystallization from diethyl ether gave 0.2 (59%) of the desired product.

1. stirringthe reaction mixture was stirred at ambient temperature for 2 h
2. customThe solvent was evaporated under reduced pressure
3. customthe residue was purified by column chromatography on silica gel
4. customCrystallization from diethyl ether