反应详情

Methyl 2,3-dimethyl-8-(2-ethyl-6-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxylate (0.4 g, 1.1 mmol) was added to a mixture of 1,4-dioxane (6 ml) and 2 M NaOH (6 ml) and was refluxed for 30 min. The dioxane was evaporated under reduced pressure and the aqueous solution was made acidic by addition of 2 M HCl. The acidic aqueous was basified by the addition of a saturated bicarbonate solution and the solid that formed was isolated by filtration to give 0.35 g (91%) of the title compound.

1. temperaturewas refluxed for 30 min
2. customThe dioxane was evaporated under reduced pressure
3. additionthe aqueous solution was made acidic by addition of 2 M HCl
4. additionThe acidic aqueous was basified by the addition of a saturated bicarbonate solution
5. customthe solid that formed
6. customwas isolated by filtration