反应详情

Ethyl 5,6-diaminonicotinate (1.4 g, 7.7 mmol) and 3-bromo-2-butanon (1.16 g, 7.2 mmol) were added to 1,2-dimethoxyethan (50 ml) and refluxed for 20 h. The solvent was evaporated under reduced pressure and the residue was dissolved in methylene chloride. The methylene chloride solution was washed with saturated sodium bicarbonate and dried (Na2SO4). The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel using methylene chloride:methanol (10:1) as eluent to give 0.3 g (17%) of the title compound.

1. temperaturerefluxed for 20 h
2. customThe solvent was evaporated under reduced pressure
3. dissolutionthe residue was dissolved in methylene chloride
4. washThe methylene chloride solution was washed with saturated sodium bicarbonate
5. dry with materialdried (Na2SO4)
6. customThe solvent was evaporated under reduced pressure
7. customthe residue was purified by column chromatography on silica gel