6-Amino-5-nitro-nicotinamide → 5,6-Diaminonicotinamide

HRID 427504Notes

Reaction equation

HRID 427504 reaction equation
[NH2:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1.[H][H]>CO.[Pd]>[NH2:11][C:10]1[C:2]([NH2:1])=[N:3][CH:4]=[C:5]([CH:9]=1)[C:6]([NH2:8])=[O:7]

Participants

5

Reactant 2

HCID 3517576-Amino-5-nitro-nicotinamideHCID 178418361HCID 178418361, compound

Product 1

HCID 99421905,6-Diaminonicotinamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 6-amino-5-nitronicotinamide (18 g, 99 mmol) and a cat. amount of Pd/C in methanol (600 ml) and the mixture was hydrogenated at room temperature and atmospheric pressure until the uptake of hydrogen ceased. Following filtration through celite, the methanol was evaporated under reduced pressure to give the title compound, 14.5 g (96%).

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationfiltration through celite
  3. customthe methanol was evaporated under reduced pressure

Sources & evidence

ORD record
ord-518f1b071aa64f4c9ea99955b17e141f
Source dataset
uspto-grants-2001_11
Patent number
US06313137B1

Reaction notes

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