反应详情

2-(2-bromo-3-methylphenyl)acetic acid (7.9 g, 0.034 mol) and sulfuric acid (0.1 ml) were added to ethanol (25 ml) and the mixture was refluxed overnight. The solvent was evaporated and to the residue was added saturated sodium carbonate. The aqueous solution was extracted twice with diethyl ether, the organic extracts were combiened, washed twice with water, dried and evaporated under reduced pressure to give the desired product as an oil. (8.5 g,97.7%).

1. temperaturethe mixture was refluxed overnight
2. customThe solvent was evaporated and to the residue
3. additionwas added saturated sodium carbonate
4. extractionThe aqueous solution was extracted twice with diethyl ether
5. washwashed twice with water
6. customdried
7. customevaporated under reduced pressure