1,3-Thiazole-2-carbaldehyde → HCID 21352790, compound

HRID 427540Notes

Reaction equation

HRID 427540 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]([C:7]([NH:9][C:10]2[C:11]([NH:16][C:17]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[O:18])=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:8])=[CH:5][CH:4]=1.[S:27]1[CH:31]=[CH:30][N:29]=[C:28]1[CH:32]=O>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][C:10]2[C:11]([NH:16][C:17]([CH:19]3[CH2:20][CH2:21][N:22]([CH2:32][C:28]4[S:27][CH:31]=[CH:30][N:29]=4)[CH2:23][CH2:24]3)=[O:18])=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:8])=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 27349031,3-Thiazole-2-carbaldehydeHCID 53635745HCID 53635745, compound

Product 1

HCID 21352790HCID 21352790, compound

Procedure

Using the general procedure described in Example 3, N1-(4-methoxybenzoyl)-N2-(piperidin-4-ylcarbonyl)-1,2-benzenediamine (0.070 mmol) was reacted with 2-thiazolecarboxaldehyde to provide 28 mg of the title product as the free base. Treatment with hydrochloric acid and concentration in vacuo yielded the salt of the title compound.

Sources & evidence

ORD record
ord-840dbd216f9d4326aeed0e623c608995
Source dataset
uspto-grants-2001_11
Patent number
US06313122B1

Reaction notes

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