HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 427549Generated: October 26, 2026
4-Bromophthalic anhydride → N-(4-Methoxybenzoyl)-2-(5-bromo-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)benzeneamine
https://huagongshe.com/reaction/427549
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Bromophthalic anhydride | HCID 66590 | — |
| Reactant | N-(2-Aminophenyl)-4-methoxybenzamide | HCID 785232 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-Methoxybenzoyl)-2-(5-bromo-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)benzeneamine | HCID 18357020 | 93.4% |
Reaction Steps
A pressure tube was charged with N1-(4-methoxybenzoyl)-1,2-benzenediamine (2.00 g, 8.26 mmol), 4-bromophthalic anhydride (1.88 g, 8.26 mmol), and tetrahydrofuran (8 mL). The resultant slurry was then placed in a bath heated to 110° C. for 16 h. After cooling to ambient temperature, the product was triturated with ethyl acetate/hexanes and collected by filtration. Recrystallization from ethyl acetate/hexanes yielded 3.48 g (93%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06313122B1 |
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| Source dataset | uspto-grants-2001_11 |
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| ORD ID | ord-53309fa63af242a193d60febcc4eee7d |
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| Source note | uspto-grants-2001_11 |
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