HCID 18174630, 화합물 → HCID 18174664, 화합물

HRID 427603노트

반응식

HRID 427603 반응식
C([O:8][C:9]1[CH:10]=[C:11]([NH:15][C:16](=[O:36])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[NH:23][C:24](=[O:35])[C:25]2[CH:30]=[CH:29][C:28]([C:31]([CH3:34])([CH3:33])[CH3:32])=[CH:27][CH:26]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.[H][H]>O1CCCC1.[Pd]>[C:31]([C:28]1[CH:29]=[CH:30][C:25]([C:24]([NH:23][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[C:16]([NH:15][C:11]2[CH:12]=[CH:13][CH:14]=[C:9]([OH:8])[CH:10]=2)=[O:36])=[O:35])=[CH:26][CH:27]=1)([CH3:34])([CH3:32])[CH3:33]

참가 물질

5

반응물 2

HCID 18174630HCID 18174630, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 18174664HCID 18174664, 화합물수율 88%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of N-(3-benzyloxyphenyl)-2-[(4-tert-butylbenzoyl)amino]benzamide (0.58 g, 1.2 mmol) in tetrahydrofuran (50 mL) was added 10% palladium-on-carbon (0.29 g). The vessel was placed under vacuum and the atmosphere was replaced with hydrogen (1 atm). After 12 h, the balloon was removed and the mixture was filtered through diatomaceous earth and concentrated in vacuo. The residue was dissolved in ethyl acetate and washed with saturated aqueous sodium chloride solution, dried (magnesium sulfate), filtered, and concentrated In vacuo to give 0.41 g (88%) of the title compound as an off-white solid.

후처리

  1. customthe balloon was removed
  2. filtrationthe mixture was filtered through diatomaceous earth
  3. concentrationconcentrated in vacuo
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. washwashed with saturated aqueous sodium chloride solution
  6. dry with materialdried (magnesium sulfate)
  7. filtrationfiltered
  8. concentrationconcentrated In vacuo

출처 및 근거

ORD 기록
ord-109ac4151d0d432ab9adf1d41ca40cc8
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313122B1

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