反应详情

To a stirred suspension of N-(4-pyridyl)isonipecotic acid (0.2 g, 1 mmol) in dichloromethane (70 mL) was added thionyl chloride (0.11 mL, 1.5 mmol). After stirring overnight, the solvent was removed in vacuo and the residue was dissolved in dichloromethane (10 mL) and added to a stirred solution of 2-amino-N-(4-methoxyphenyl)benzamide (0.186 g, 0.77 mmol) and pyridine (0.19 g, 0.85 mmol) in dichloromethane (25 mL). After stirring for 72 h, the solution was transferred to a separatory funnel and washed with water, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. The organic phase was dried (magnesium sulfate), filtered, and concentrated in vacuo. The residue was suspended in a mixture of diethyl ether and hexanes, sonicated, and filtered. The resulting solid was washed with diethyl ether and dried in vacuo to give 0.10 g (30%) of the title compound as a pale tan solid.

1. customthe solvent was removed in vacuo
2. dissolutionthe residue was dissolved in dichloromethane (10 mL)
3. stirringAfter stirring for 72 h
4. customthe solution was transferred to a separatory funnel
5. washwashed with water, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
6. dry with materialThe organic phase was dried (magnesium sulfate)
7. filtrationfiltered
8. concentrationconcentrated in vacuo
9. additionThe residue was suspended in a mixture of diethyl ether and hexanes
10. customsonicated
11. filtrationfiltered
12. washThe resulting solid was washed with diethyl ether
13. customdried in vacuo