4-Methylbenzoyl Chloride → HCID 86585761, compound

HRID 427645Notes

Reaction equation

HRID 427645 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([CH2:13][O:14][C:15]([NH:17][NH:18][C:19]3[C:20]([NH2:25])=[CH:21][CH:22]=[CH:23][CH:24]=3)=[O:16])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH3:26][C:27]1[CH:35]=[CH:34][C:30]([C:31]([Cl:33])=[O:32])=[CH:29][CH:28]=1>>[ClH:33].[CH3:26][C:27]1[CH:35]=[CH:34][C:30]([C:31]([NH:25][C:20]2[C:19]([NH:18][NH:17][C:15]([O:14][CH2:13][CH:10]3[CH2:9][CH2:8][N:7]([C:4]4[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=4)[CH2:12][CH2:11]3)=[O:16])=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:32])=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 134054-Methylbenzoyl ChlorideHCID 18174491HCID 18174491, compound

Product 1

HCID 86585761HCID 86585761, compoundYield 56%

Procedure

Using the procedure described in Example 48, Part C, N1-[[1-(4-pyridyl)piperidin-4-yl]methoxycarbonylamino]-1,2-benzenediamine (0.61 mmol) and 4-methylbenzoyl chloride (1.2 mmol) yielded 164 mg (56%) of the title compound.

Sources & evidence

ORD record
ord-1d11ad44b9e242cd8e3b4041670e33bd
Source dataset
uspto-grants-2001_11
Patent number
US06313122B1

Reaction notes

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