反应详情

Using the procedure described in Example 161, 5-oxo-5-morpholinopentanoic acid (166 mg, 0.826 mmol) was reacted with N1-(4-methoxybenzoyl)-1,2-benzenediamine. The reaction mixture was diluted with additional methylene chloride and washed with 1 N aqueous sodium hydroxide. The organic phase was washed with 1 N aqueous hydrochloric acid, dried (sodium sulfate), filtered, and concentrated in vacuo to provide 300 mg (85%) of the title compound as an amorphous white solid.

1. washwashed with 1 N aqueous sodium hydroxide
2. washThe organic phase was washed with 1 N aqueous hydrochloric acid
3. dry with materialdried (sodium sulfate)
4. filtrationfiltered
5. concentrationconcentrated in vacuo