HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chlorofuran-2-carboxylic acid → N1-(5-Chlorofuran-2-ylcarbonyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl]-1,2-benzenediamine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chlorofuran-2-carboxylic acid | HCID 234853 | — |
| Reactant | N1-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl)-1,2-benzenediamine | HCID 86585755 | — |
| Product | N1-(5-Chlorofuran-2-ylcarbonyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl]-1,2-benzenediamine Hydrochloride | HCID 86585766 | 22% |
Reaction Steps
Using the procedure described in Example 168, N1-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl]-1,2-benzenediamine (0.61 mmol) and 5-chloro-2-furancarboxylic acid (1.2 mmol), purifying with RPHPLC Method A, yielded 57 mg (22%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313122B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-a26ce0ab3e6047c7a32baa40e02ae8d7 |
| Source note | uspto-grants-2001_11 |