1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → 4,5-Difluoro-2-[[1-(4-pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-methoxyphenyl)benzamide Hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	1-(4-Pyridinyl)-4-piperidinecarbonyl chloride	HCID 11183700	—
Reactant	N-(4-methoxyphenyl)-2-amino-4,5-difluorobenzamide	HCID 18174583	—
Product	4,5-Difluoro-2-[[1-(4-pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-methoxyphenyl)benzamide Hydrochloride	HCID 18174479	57%

Reaction Steps

Using the procedure described in Example 138, N-(4-methoxyphenyl)-2-amino-4,5-difluorobenzamide (1.8 mmol) and N-(4-pyridyl)isonipecotoyl chloride (3.6 mmol), purifying with RPHPLC Method A, yielded 505 mg (57%) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06313122B1
Source dataset	uspto-grants-2001_11
ORD ID	ord-2fc1f2137ce64f7b86d7b59a2f99604c
Source note	uspto-grants-2001_11