HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → 4-Fluoro-2-[[1-(4-pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-methoxyphenyl)benzamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Pyridinyl)-4-piperidinecarbonyl chloride | HCID 11183700 | — |
| Reactant | N-(4-methoxyphenyl)-2-amino-4-fluorobenzamide | HCID 18174610 | — |
| Product | 4-Fluoro-2-[[1-(4-pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-methoxyphenyl)benzamide Hydrochloride | HCID 18174513 | 78% |
Reaction Steps
Using the procedure described in Example 138, N-(4-methoxyphenyl)-2-amino-4-fluorobenzamide (1.8 mmol) and N-(4-pyridyl)isonipecotoyl chloride (3.6 mmol), purifying with RPHPLC Method A, yielded 677 mg (78%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313122B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-b30c7b6e8afc4618b0230859ab223685 |
| Source note | uspto-grants-2001_11 |