HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-amino-N-(4-fluorophenyl)benzamide → 2-[[1-(4-Pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-fluorophenyl)benzamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-amino-N-(4-fluorophenyl)benzamide | HCID 478822 | — |
| Reactant | 1-(4-Pyridinyl)-4-piperidinecarbonyl chloride | HCID 11183700 | — |
| Product | 2-[[1-(4-Pyridyl)piperidin-4-ylcarbonyl]amino]-N-(4-fluorophenyl)benzamide Hydrochloride | HCID 18174451 | 35% |
Reaction Steps
Using the procedure described in Example 138, N-(4-fluorophenyl)-2-aminobenzamide (0.92 mmol) and N-(4-pyridyl)isonipecotoyl chloride (1.8 mmol), purifying with RPHPLC Method A, yielded 146 mg (35%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313122B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-138d50ea0d944c28934f96cd38175e2d |
| Source note | uspto-grants-2001_11 |