2-Nitrophenyl isocyanate → 2-[1-(4-Pyridyl)piperidin-4-ylmethylaminocarbonyl]amino-nitrobenzene

HRID 427707Notes

Reaction equation

HRID 427707 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([CH2:13][NH2:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[N+:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[N:24]=[C:25]=[O:26])([O-:17])=[O:16]>>[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:8][CH2:9][CH:10]([CH2:13][NH:14][C:25]([NH:24][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[N+:15]([O-:17])=[O:16])=[O:26])[CH2:11][CH2:12]2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 768342-Nitrophenyl isocyanateHCID 10607746[1-(Pyridin-4-yl)piperidin-4-yl]methanamine

Product 1

HCID 181744692-[1-(4-Pyridyl)piperidin-4-ylmethylaminocarbonyl]amino-nitrobenzeneYield 64%

Procedure

Using a similar procedure to that described for Example 48, Part A, 1-(4-pyridyl)piperidine-4-methylamine (1.34 g, 7.01 mmol) and 2-nitrophenyl isocyanate (1.21 g, 7.40 mmol) yielded 1.59 g (64%) of the title compound.

Sources & evidence

ORD record
ord-29518fc921bc4e1297fc943a5bbef2e0
Source dataset
uspto-grants-2001_11
Patent number
US06313122B1

Reaction notes

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