HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 427722Generated: October 30, 2026
Sodium Hydroxide → 6-[(Pyridin-2-yl)methoxy]pyridin-3-amine
https://huagongshe.com/reaction/427722
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 2-(Pyridin-2-ylmethoxy)-5-nitropyridine | HCID 18357725 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-[(Pyridin-2-yl)methoxy]pyridin-3-amine | HCID 15447788 | 78% |
Reaction Steps
5-Nitro-2-(pyridin-2-ylmethyloxy)pyridine (D1, 2.0 g, 0.0087 mole) in ethanol (70 ml) was treated with tin (II) chloride (8.3 g, 0.044 mole) in conc. HCl (15 ml). The mixture was heated to 50° C. for 0.5 hour. After cooling to room temperature, the mixture was diluted with water, basified with 10% aqueous sodium hydroxide solution, extracted into ethyl acetate, dried (Na2SO4) and evaporated in vacuo to afford the title compound (1.36 g, 78%) as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06313145B1 |
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| Source dataset | uspto-grants-2001_11 |
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| ORD ID | ord-19bdabcaa6ba44608332a5b83fb7d5f1 |
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| Source note | uspto-grants-2001_11 |
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