反应详情

(5-Methoxy-2-nitro4-trifluoromethylphenyl)acetonitrile (D7) (85 g, 0.327 mol) in ethanol/water (9:1, 1.6 l) and glacial acetic acid (16 ml) was hydrogenated over 10% palladium on carbon (50 g) at 50 psi for 0.5 h at room temperature. The reaction mixture was filtered and evaporated in vacuo. The residue was partitioned between aqueous K2CO3 (1 l) and dichloromethane (2×1 l) and the combined organic extract was dried (Na2SO4) and evaporated to afford the title indole (67.63 g, 96%) as a grey solid.

1. filtrationThe reaction mixture was filtered
2. customevaporated in vacuo
3. customThe residue was partitioned between aqueous K2CO3 (1 l) and dichloromethane (2×1 l)
4. extractionthe combined organic extract
5. dry with materialwas dried (Na2SO4)
6. customevaporated