反应详情

A suspension of 2-benzyloxy-5-bromobenzaldehyde (14.5 g, 50.2 mmol) in absolute ethanol (250 ml) was treated with sodium borohydride (2.6 g, 68.8 mmol). The reaction was stirred and the temperature slowly rose to 33° C. After 1 hour the reaction mixture was evaporated and the residue dissolved in ethyl acetate and poured into a mixture of ice water (200 ml) and 1N HCl (25 ml). The organic layer was separated, washed with aqueous sodium hydrogen carbonate, brine, dried (Na2SO4) and evaporated to give 2-benzyloxy-5-bromobenzyl alcohol as a pale yellow oil (14.85 g, quantitative).

1. customslowly rose to 33° C
2. customAfter 1 hour the reaction mixture was evaporated
3. dissolutionthe residue dissolved in ethyl acetate
4. additionpoured into a mixture of ice water (200 ml) and 1N HCl (25 ml)
5. customThe organic layer was separated
6. washwashed with aqueous sodium hydrogen carbonate, brine
7. dry with materialdried (Na2SO4)
8. customevaporated