Hydrochloric Acid → Phenylacetic Acid

Participants

Reaction Steps

1N sodium hydroxide solution (10 ml) was added to a solution of ethyl (E)-α-methoxy-2-((α-methyl-4-chlorobenzylideneaminooxymethyl)phenylacetate (0.70 g, 1.9 mmol) in methanol (10 ml), and the mixture was stirred at room temperature for 2 hours. The mixture was adjusted to pH 4 with 1N hydrochloric acid, extracted with methylene chloride and dried over anhydrous magnesium sulfate. Evaporation of the solvent gave the desired compound (E)-α-methoxy-2-α-methyl-4-chlorobenzylideneaminooxymethyl)phenylacetic acid (0.50 g, 77%) as an oil.

Provenance & Evidence