o-Tolylacetic acid → 2-[(2-methylphenyl)acetamido]butyric Acid Iso-butyl Ester

HRID 428085Notes

Reaction equation

HRID 428085 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH3:1])[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 69519o-Tolylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 545734982-[(2-methylphenyl)acetamido]butyric Acid Iso-butyl Ester

Procedure

Following General Procedure I above and using 2-methylphenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-dd248d6ecbb34d9285c8857df5e4bd6d
Source dataset
uspto-grants-2001_11
Patent number
US06313152B1

Reaction notes

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