Cyclopropanemethanol → HCID 54227421, compound

HRID 428096Notes

Reaction equation

HRID 428096 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH:11][C@H:12]([C:14]([OH:16])=[O:15])[CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH:17]1([CH2:20]O)[CH2:19][CH2:18]1>>[CH:17]1([CH2:20][O:15][C:14](=[O:16])[C@H:12]([CH3:13])[NH:11][C:9](=[O:10])[CH2:8][C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 75644CyclopropanemethanolHCID 15481783N-(3-chlorophenylacetyl)alanine

Product 1

HCID 54227421HCID 54227421, compound

Procedure

Following General Procedure C above, and using N-(3-chlorophenylacetyl alanine (from Example D above) and cyclopropylmethanol (Aldrich), the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 3:7 EtOAc:hexane as the eluant.

Sources & evidence

ORD record
ord-26ea83ee9626411d89bf999ccba75587
Source dataset
uspto-grants-2001_11
Patent number
US06313152B1

Reaction notes

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