2-(1-Benzofuran-2-yl)acetic acid → N-[(benzofuran-2-yl)acetyl]alanine Iso-butyl Ester

HRID 428102Notes

Reaction equation

HRID 428102 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10][C:11]([OH:13])=O.[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH2:21])[CH:15]([CH3:17])[CH3:16]>>[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH:21][C:11](=[O:13])[CH2:10][C:2]1[O:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=1)[CH:15]([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 111058882-(1-Benzofuran-2-yl)acetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 15481779N-[(benzofuran-2-yl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure I above, and using benzofuran-2-ylacetic acid (Maybridge) and alanine iso-butyl ester (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-1f5df25fe21f445d8ef6f6132651ba5a
Source dataset
uspto-grants-2001_11
Patent number
US06313152B1

Reaction notes

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